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DTSTAMP:20260405T110354Z
UID:617b995f60f6d760856404@ist.ac.at
DTSTART:20211116T153000
DTEND:20211116T163000
DESCRIPTION:Speaker: Lisa Monteggia\nhosted by Mojtaba Tavakoli (Danzl Grou
 p)\nAbstract: Major depressive disorder is one of the most prevalent menta
 l illnesses. Traditional antidepressants\, which target the monoamine syst
 em\, are commonly prescribed for the treatment of depression but they typi
 cally take several weeks to exert a clinical effect\, with a sizable fract
 ion of the patients failing to respond to treatment. This therapeutic dela
 y in onset is a major limitation of traditional antidepressant therapies e
 specially for individuals at risk for suicide. Thus\, there has been a sig
 nificant unmet need for the development of pharmacological therapies that 
 can quickly and effectively alleviate symptoms associated with depression.
  Ketamine is a noncompetitive glutamatergic N-methyl-D-aspartate receptor 
 (NMDAR) antagonist with rapid antidepressant efficacy for patients with tr
 eatment-resistant major depressive disorder. We have been investigating th
 e mechanisms underlying the efficacy of rapid antidepressant action using 
 preclinical animal models. We previously showed that ketamine blocks NMDAR
 s activated by spontaneous glutamate release (also referred to as at rest)
  that couples to eukaryotic elongation factor 2 kinase (eEF2K) signaling. 
 This signaling pathway subsequently results in increased protein synthesis
  including brain-derived neurotrophic factor (BDNF) and a-amino-3-hydroxy-
 5-methylisoxazole-4-propinic acid receptors (AMPARs) that results in a rob
 ust and persistent potentiation of AMPA receptor-mediated transmission in 
 Schaffer collateral to CA1 synapses that is necessary for rapid antidepres
 sant effects. This presentation will focus on the key synaptic mechanisms 
 underlying rapid antidepressant action\, including the specific role of eE
 F2K in synaptic function\, as well as the long-term antidepressant effects
 .
LOCATION:Online Event (https://istaustria.zoom.us/j/97414233454?pwd=Y3FibW9
 LY21wQ29qMG9wZTJxQkF6dz09\, Meeting ID: 974 1423 3454\, Passcode: 482716)\
 , ISTA
ORGANIZER:lmarr@ist.ac.at
SUMMARY:Lisa Monteggia: Synaptic mechanisms underlying rapid antidepressant
  action
URL:https://talks-calendar.ista.ac.at/events/3404
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