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DTSTART:20170326T030000
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DTSTART:20161030T020000
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BEGIN:VEVENT
DTSTAMP:20260428T111747Z
UID:58ad96abc88c4816235977@ist.ac.at
DTSTART:20170313T110000
DTEND:20170313T120000
DESCRIPTION:Speaker: Otger Campàs\nhosted by Carl-Philipp Heisenberg\nAbst
 ract: The sculpting of tissues into their functional morphologies requires
  a tight spatiotemporal control of their mechanics. While cell-generated m
 echanical forces power morphogenesis\, the resulting tissue movements depe
 nd on the local tissue mechanical properties\, such as its stiffness and v
 iscosity\, which govern the system's response to the internally generated 
 forces. Despite their relevance\, the role of mechanical forces and mechan
 ical properties in development processes remains largely unknown\, mainly 
 because of a lack in methodologies enabling direct in vivo and in situ mea
 surements of cell-generated forces and mechanical properties within develo
 ping 3D tissues and organs. In this talk\, I will present two novel microd
 roplet-based techniques that we have recently developed to quantify local 
 cellular forces and mechanical properties within developing 3D tissues. Us
 ing zebrafish as model system\, I will show that cellular forces do not va
 ry strongly in space and time\, whereas spatiotemporal changes in supra-ce
 llular (tissue level) forces and mechanical properties correlate with morp
 hogenetic events and spatial variations in cellular movements. These resul
 ts indicate that spatiotemporal changes in tissue mechanical properties (s
 tiffness\, fluidity\, etc.)\, rather than just cellular forces\, regulate 
 the sculpting of embryonic tissues.
LOCATION:Experimental Biology Room (I04.2OG - LAB)\, ISTA
ORGANIZER:lalesch@ist.ac.at
SUMMARY:Otger Campàs: Mechanical control of tissue morphogenesis
URL:https://talks-calendar.ista.ac.at/events/336
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