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DTSTART:20210328T030000
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DTSTAMP:20260406T000457Z
UID:616c7e8cd4696863475084@ist.ac.at
DTSTART:20211019T160000
DTEND:20211019T170000
DESCRIPTION:Speaker: Keisuke Ishihara\nhosted by Martin Loose & Edouard Han
 nezo\nAbstract: Animal organs exhibit complex topologies involving cavitie
 s and tubular networks\, which underlie their form and function. However\,
  how topology emerges during organ morphogenesis remains elusive. In this 
 seminar\, I will present our recent work\, where we combined tissue recons
 titution and quantitative microscopy to show that trans and cis epithelial
  fusion govern tissue topology and shape. These two modes of topological t
 ransitions can be regulated in neuroepithelial organoids\, leading to dive
 rgent topologies as found from live imaging. We develop a theory to explai
 n the mechanical basis of epithelial fusion\, and find that the morphologi
 cal space is captured by a single control parameter analogous to the reduc
 ed Gaussian rigidity of an epithelial surface. Finally\, we identify lysop
 hosphatidic acid synthesis as a pharmacologically accessible pathway that 
 regulates the frequency of trans and cis fusion\, and demonstrate the cont
 rol of organoid topology and shape. Our findings leads to future research 
 for the characterization\, prediction\, and control of multicellular morph
 ogenesis\, enabling the advanced engineering of organoid form and function
 .
LOCATION:Big Seminar Room B (big) 63 seats (I23.EG.102)\, ISTA
ORGANIZER:mloose@ist.ac.at
SUMMARY:Keisuke Ishihara: Topological morphogenesis of neuroepithelial orga
 noids
URL:https://talks-calendar.ista.ac.at/events/3342
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