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DTSTART:20170326T030000
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DTSTART:20161030T020000
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DTSTAMP:20260428T192947Z
UID:58ac00d96c98a292994999@ist.ac.at
DTSTART:20170224T160000
DTEND:20170224T170000
DESCRIPTION:Speaker: Peter Koppensteiner\nhosted by Ryuichi Shigemoto\nAbst
 ract: The medial habenula-interpeduncular nucleus (MHb-IPN) pathway which 
 connects the limbic forebrain to the midbrain\, has recently been implicat
 ed in aversive behaviors. The MHb-IPN circuit is characterized by a unique
  topographical organization\, an excitatory role of GABA and a prominent c
 o-release of neurotransmitters and neuropeptides. However\, little is know
 n about synaptic plasticity in this pathway. An application of high-freque
 ncy stimulation resulted in a long-lasting potentiation of glutamate relea
 se in IPN neurons. This plasticity required the activation of post-synapti
 c Ca2+-permeable AMPA receptors (CPARs) and pre-synaptic GABAB receptors. 
 Strikingly\, adolescent IPN neurons lacked CPARs and exhibited an inabilit
 y to undergo plasticity. Our experiments reveal that CPAR-dependent releas
 e of GABA from IPN neurons and retrograde activation of GABAB receptors on
  MHb terminals result in a long-lasting enhancement of glutamate release. 
 This plasticity at the MHb-IPN synapses might be critical for the regulati
 on of aversive behaviors\, which is altered during adolescence.\n
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:ddomniso@ist.ac.at
SUMMARY:Peter Koppensteiner: A cooperative mechanism involving Ca2+-permeab
 le AMPA receptors and retrograde activation of GABAB receptors in interped
 uncular nucleus plasticity 
URL:https://talks-calendar.ista.ac.at/events/331
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