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DTSTART:20180325T030000
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DTSTART:20171029T020000
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DTSTAMP:20260424T051523Z
UID:577e0fffc26b1318291763@ist.ac.at
DTSTART:20171127T160000
DTEND:20171127T170000
DESCRIPTION:Speaker: Marcos Gonzalez-Gaitan\nhosted by Carl-Philipp Heisenb
 erg\nAbstract: During asymmetric division\, fate determinants at the cell 
 cortex segregate unequally into the two daughter cells. It has recently be
 en shown that Sara signaling endosomes in the cytoplasm also segregate asy
 mmetrically during asymmetric division. Biased dispatch of Sara endosomes 
 mediates asymmetric Notch/Delta signaling during the asymmetric division o
 f sensory organ precursors in Drosophila. In flies\, this has been general
 ized to stem cells in the gut and the central nervous system and\, in ze
 brafish\, to neural precursors of the spinal cord. However\, the mechanism
  of asymmetric endosome segregation is not known. We unravelled now this m
 echanism. The plus-end kinesin motor Klp98A targets Sara endosomes to the 
 central spindle. At the central spindle\, endosomes move bidirectionally o
 n an antiparallel array of microtubules. The microtubule depolymerising ki
 nesin Klp10A and its antagonist Patronin generate central spindle asymmetr
 y. The asymmetric spindle\, in turn\, polarizes endosome motility\, ultima
 tely causing asymmetric endosome dispatch into one daughter cell. Spindle 
 inversion targets the endosomes to the wrong cell. Our data uncovers the m
 olecular and physical mechanism by which organelles localized away from th
 e cellular cortex can be dispatched asymmetrically during asymmetric divis
 ion.
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:kzaruba@ist.ac.at
SUMMARY:Marcos Gonzalez-Gaitan: Asymmetric signaling endosomes in asymmetri
 c division
URL:https://talks-calendar.ista.ac.at/events/33
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