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DTSTART:20210328T030000
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DTSTAMP:20260408T225033Z
UID:610bdd697c064563346140@ist.ac.at
DTSTART:20210825T110000
DTEND:20210825T120000
DESCRIPTION:Speaker: Arnau Sans Dublanc\nhosted by Maximilian Jösch\nAbstr
 act: Neuronal cell-types are arranged in brain-wide circuits that guide be
 havior. However\, current approaches have fostered a reductionist conceptu
 alization identifying specific mono- or di-synaptic circuits as necessary 
 and sufficient for a behavior. This can promote observational biases and h
 inder the discovery of potentially critical unobserved cell-populations\, 
 pathways and the interactions between them. To avoid this\, during my PhD\
 , I combined functional ultrasound imaging (fUSI) with optogenetics to rev
 eal the brain-wide networks activated by specific genetically defined cell
 -types. I used this framework to investigate 4 distinct cell-types in the 
 mouse superior colliculus\, a midbrain area that mediates innate orienting
  and defensive behaviors. This approach allowed me to identify new brain a
 reas involved in colliculus-driven behaviors and demonstrate that each cel
 l-type mediates behavior via a broad yet distinct downstream network of br
 ain regions. related publication:Sans-Dublanc A\, Chrzanowska A\, Reinhard
  K\, Lemmon D\, Nuttin B\, Lambert T\, Montaldo G\, Urban A\, Farrow K. Op
 togenetic fUSI for brain-wide mapping of neural activity mediating collicu
 lar-dependent behaviors. Neuron. 2021 Jun 2\;109(11):1888-1905.e10. doi: 1
 0.1016/j.neuron.2021.04.008. Epub 2021 Apr 29. PMID: 33930307.
LOCATION:Heinzel Seminar Room / Office Bldg West (I21.EG.101)\, ISTA
ORGANIZER:rsix@ist.ac.at
SUMMARY:Arnau Sans Dublanc: Optogenetic fUSI for brain-wide mapping of neur
 al activity mediating collicular-dependent behaviors
URL:https://talks-calendar.ista.ac.at/events/3249
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