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DTSTAMP:20260405T202447Z
UID:60a7a708de6b1812229960@ist.ac.at
DTSTART:20210525T093000
DTEND:20210525T113000
DESCRIPTION:Speaker: Jake Yeung\nhosted by Mario de Bono & Beatriz Vicoso\n
 Abstract: Cells are the basic units of life. Although every cell in the bo
 dy have essentially the same genetic code\, chromatin states in the genome
  regulate different genes and allow distinct cells to perform specific fun
 ctions. Recently\, new sequencing techniques have begun to map these chrom
 atin states at the single-cell level\, opening up new opportunities to inf
 er gene regulatory principles at unprecedented resolutions. In this talk\,
  I present two projects integrating these technologies with statistical fr
 ameworks to reveal global insights in chromatin regulation in single cells
 .First\, I present a new technology\, sortChIC (sort-assisted chromatin im
 munocleavage)\, and apply it to understand chromatin regulation during blo
 od formation. I highlight how to model these sparse high-dimensional count
  data to predict regulators driving blood formation. Specifically\, I infe
 r transcription factor activities in single cells\, revealing how blood st
 em cells rewire regulatory networks to become distinct mature blood cell t
 ypes. Second\, I present scChIX (single-cell chromatin immunocleavage and 
 unmixing)\, an integrated statistical and experimental framework to unders
 tand the interplay between histone modifications in single cells. scChIX g
 enerates linked maps of active and repressive chromatin\, allowing integra
 ted analysis of different histone modifications in single cells. These lin
 ked maps reveal switching between active and repressive states during deve
 lopment of B cells in the blood. Overall\, combining theory\, design\, and
  analysis into sequencing technologies reveals global gene regulatory prin
 ciples.
LOCATION:Online Event ()\, ISTA
ORGANIZER:lalesch@ist.ac.at
SUMMARY:Jake Yeung: Theory\, design\, and analysis of single-cell sequencin
 g experiments to understand gene regulation
URL:https://talks-calendar.ista.ac.at/events/3206
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