BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20170326T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20161030T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260428T110339Z
UID:58a2fb92ad125606162068@ist.ac.at
DTSTART:20170223T140000
DTEND:20170223T150000
DESCRIPTION:Speaker: Nael Nadif Kasri\nhosted by Gaia Novarino\nAbstract: N
 eurodevelopmental disorders (NDDs)\, including intellectual disability (ID
 ) and autism spectrum disorders (ASD)\, are phenotypically and genotypical
 ly heterogeneous. The molecular pathways involved in these disorders\, how
 ever\, are rapidly being elucidated by the identification of mutations in 
 genes that cause cognitive impairments in humans. While the identification
  of disease genes has great benefits for diagnostic and prognostic purpose
 s\, for the vast majority of these genes\, there is little conceptual know
 ledge about neurobiological mechanisms that they control at the cellular a
 nd network level. \nOne emerging group of NDDs\, named chromatinopathies\,
  are caused by mutations in epigenetic regulators of gene expression. We h
 ave recently identified Euchromatin Histone Methyltransferase 1 (EHMT1) as
  a key modulator in cognition. Heterozygous loss-of-function alleles of th
 is gene cause a specific ID syndrome\, denoted Kleefstra syndrome\, which 
 is characterized by moderate-severe ID\, autism\, microcephaly\, and dysmo
 rphic features. EHMT1/GLP cooperates with its mammalian paralog EHMT2/G9a 
 and exhibits enzymatic activity in histone 3 lysine 9 mono-and di-methylat
 ion (H3K9me1 and H3K9me2)\, which is known to promote heterochromatic stru
 cture and gene repression. Here  I will discuss our recent advances toward
 s understanding the contribution of epigenetic regulation of gene expressi
 on\, through H3K9me2\, in learning and memory and specific forms of synapt
 ic plasticity in rodent and hIPSC models.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:ddomniso@ist.ac.at
SUMMARY:Nael Nadif Kasri: Genetics of epigenetics: relevance for cognitive 
 disorders
URL:https://talks-calendar.ista.ac.at/events/318
END:VEVENT
END:VCALENDAR