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DTSTART:20210328T030000
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DTSTAMP:20260405T161901Z
UID:604f483aed864699382249@ist.ac.at
DTSTART:20210416T150000
DTEND:20210416T160000
DESCRIPTION:Speaker: Carles Blanch-Mercader\nAbstract: Quantifying material
  properties of cell monolayers by analyzing integer topological defectsMon
 olayers of anisotropic cells exhibit long-ranged orientational order and t
 opological defects. During the development of organisms\, orientational or
 der often influences morphogenetic events. However\, the linkage between t
 he mechanics of cell monolayers and topological defects remains largely un
 explored. Here\, we build on the physics of liquid crystals to determine m
 aterial parameters of cell monolayers. In particular\, we use a hydrodynam
 ical description of an active polar fluid to study the steady-state mechan
 ical patterns around integer topological defects. We apply our approach to
  C2C12 cell monolayers in small circular confinements\, which form isolate
 d aster or spiral topological defects. By analyzing the velocity and orien
 tational order fields in spirals as well as the forces and cell number den
 sity fields in asters\, we determine mechanical parameters of C2C12 cell m
 onolayers. Our work shows how topological defects can be used to character
 ize the mechanical properties of biological materials. At the end of the p
 resentation\, I will discuss how these findings can help one interpreting 
 the temporal evolution of C2C12 cell monolayers to complex 3D structures\,
  such as localized cell differentiation and formation of cell mounds.
LOCATION:Online Event ()\, ISTA
ORGANIZER:ssengupt@ist.ac.at
SUMMARY:Carles Blanch-Mercader: Frisbi
URL:https://talks-calendar.ista.ac.at/events/3140
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