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DTSTART:20170326T030000
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DTSTART:20161030T020000
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DTSTAMP:20260428T224335Z
UID:588b19ab463b3311716723@ist.ac.at
DTSTART:20170301T130000
DTEND:20170301T140000
DESCRIPTION:Speaker: Andrew Carter\nhosted by Martin Loose\nAbstract: Cells
  depend on components being moved to the correct place at the correct time
 . My group is interested in cytoplasmic dynein-1 (dynein-1)\, a motor whic
 h delivers many different cargos via the microtubule network. When dynein-
 1 is mutated it leads to neurodegeneration and it is susceptible to hijack
  by viruses which use it to travel into the cell.  We have determined X-ra
 y crystal structures of the dynein motor before and after it binds and hyd
 rolyses ATP.  We subsequently used single molecule fluorescence assays to 
 show how a cofactor\, dynactin\, activates the full length 1.4MDa dynein c
 omplex to move long distances along microtubules.  A high resolution (4.0
 Å) cryo-electron microscopy (cryo-EM) structure of dynactin explained how
  this 23 subunit complex is assembled.  We also used a combination of cryo
 -EM and X-ray crystallography to show how dynactin binds to dynein. The tw
 o complexes are only brought together in the presence of an adaptor protei
 n\, Bicaudal-D2\, that links them to the cargo they will carry.  This sugg
 ests the large and intricate dynein/dynactin transport machine only assemb
 les when a cargo is ready to move.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:rsix@ist.ac.at
SUMMARY:Andrew Carter: Transporting cargos over long distances: insight fro
 m dynein/dynactin structures
URL:https://talks-calendar.ista.ac.at/events/314
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