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DTSTART:20210328T030000
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DTSTAMP:20260404T110251Z
UID:604f4615e3704806232469@ist.ac.at
DTSTART:20210409T150000
DTEND:20210409T160000
DESCRIPTION:Speaker: Christoph Zechner\nAbstract: Noisy biological systems 
 in compartmentalized environmentsChemical reactions serve as central units
  for cellular information processing and control. However\, many biochemic
 al processes in cells take place in highly dynamic and compartmentalized e
 nvironments\, such as networks of interacting organelles. Effective theore
 tical models to study the interplay between noisy reaction dynamics and co
 mpartmentalization are sparse and in this talk\, I will present some recen
 t progress towards addressing this problem. In the first part of the talk\
 , I will discuss how protein concentration fluctuations\, which may arise 
 from stochastic events in gene expression\, are affected when the protein 
 demixes into distinct liquid phases. Using a simple theoretical model that
  links protein concentration fluctuations to the physics of phase separati
 on\, I will show that concentration fluctuations can be significantly atte
 nuated in the presence of phase separated compartments. I will present exp
 erimental single-cell data\, which support this prediction. Later in my pr
 esentation\, I will briefly talk about a more general mathematical formali
 sm to describe stochastic reaction dynamics in compartmentalized environme
 nts and discuss potential applications to biology.
LOCATION:Online Event ()\, ISTA
ORGANIZER:ssengupt@ist.ac.at
SUMMARY:Christoph Zechner: Frisbi
URL:https://talks-calendar.ista.ac.at/events/3139
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