BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20210328T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20211031T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260404T141614Z
UID:1619787600@ist.ac.at
DTSTART:20210430T150000
DTEND:20210430T160000
DESCRIPTION:Speaker: Indira Raman\nhosted by Chaitanya Chintaluri\nAbstract
 : The cerebellum permits a wide range of behaviors that involve sensorimo
 tor integration. We have been investigating how specific cellular and sy
 naptic specializations of cerebellar neurons measured in vitro\, give r
 ise to circuit activity in vivo. We have investigated these issues by s
 tudying Purkinje neurons as well as the large neurons of the mouse cerebe
 llar nuclei\, which form the major excitatory premotor projection from t
 he cerebellum. Large CbN cells have ion channels that favor spontaneous 
 action potential firing and GABAA receptors that generate ultra-fast inh
 ibitory synaptic currents\, raising the possibility that these biophysica
 l attributes may permit CbN cells to respond differently to the degree o
 f temporal coherence of their Purkinje cell inputs. In vivo\, self-init
 iated motor programs associated with whisking correlates with asynchrono
 us changes in Purkinje cell simple spiking that are asynchronous across t
 he population. The resulting inhibition converges with mossy fiber excit
 ation to yield little change in CbN cell firing\, such that cerebellar o
 utput is low or cancelled. In contrast\, externally applied sensory stim
 uli elicits a transient\, synchronous inhibition of Purkinje cell simple 
 spiking. During the resulting strong disinhibition of CbN cells\, sensor
 y-induced excitation from mossy fibers effectively drives cerebellar out
 puts that increase the magnitude of reflexive whisking. Purkinje cell syn
 chrony\, therefore\, may be a key variable contributing to the “positive
  effort” hypothesized by David Marr in 1969 to be necessary for cerebe
 llar control of movement.
LOCATION:Online\, ISTA
ORGANIZER:
SUMMARY:Indira Raman: Synchrony and Synaptic Signaling in Cerebellar Circui
 ts
URL:https://talks-calendar.ista.ac.at/events/3133
END:VEVENT
END:VCALENDAR