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DTSTART:20170326T030000
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DTSTART:20161030T020000
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DTSTAMP:20260429T024543Z
UID:58a16bfcbba14968155109@ist.ac.at
DTSTART:20170315T133000
DTEND:20170315T150000
DESCRIPTION:Speaker: Nicola Gritti\nhosted by Anna Kicheva\nAbstract: The d
 evelopment of multicellular organisms is an extremely complex and reliable
  process\, in which single cells as well as entire tissues and organs must
  organize to give rise to an healthy adult capable of reproduction. Such a
  complex process is robust\, meaning that mistakes hardly occur despite th
 e presence of intrinsic molecular fluctuations in the underlying biology\,
  which is often referred to as noise. However\, the mechanisms that allow 
 multicellular organisms to develop reliably despite biological noise are o
 ften poorly understood. In my talk\, I give an overview of my PhD project\
 , which aims to contribute to the understanding of the role of noise in th
 e development of the nematode worm C. elegans.\n\nBecause of the intrinsic
  stochastic nature of developmental events\, the best strategy to elucidat
 e the underlying dynamics is to follow these processes over long periods o
 f time. However\, a technique which allows time-lapse microscopy of live a
 nimals over developmental time scales is currently lacking. In the first p
 art of my talk\, I introduce the technique we have developed in order to p
 erform time-lapse microscopy at single cell resolution of single live C. e
 legans larvae over the full post-embryonic development. Next\, I demonstra
 te the power of our technique\, by analyzing for the first time the animal
 -to-animal variability in i) the temporal regulation of stem-cell like div
 isions and ii) the dynamics of oscillatory gene expression. Finally\, I us
 e our novel approach to elucidate the role of noise in the stochastic AC/V
 U cell fate decision. In this way\, I show that the dynamical information 
 captured by our approach provides new insights into the mechanisms control
 ling developmental processes.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:astawick@ist.ac.at
SUMMARY:Nicola Gritti: Time-lapse microscopy study of noise in development
URL:https://talks-calendar.ista.ac.at/events/311
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