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BEGIN:VEVENT
DTSTAMP:20260406T000500Z
UID:1611928800@ist.ac.at
DTSTART:20210129T150000
DTEND:20210129T160000
DESCRIPTION:Speaker: Jeehyun Kwag\nhosted by Everton Agnes\nAbstract: Neura
 l codes\, such as temporal codes (precisely timed spikes) and rate codes (
 instantaneous spike firing rates)\, are believed to be used in encoding se
 nsory information into spike trains of cortical neurons. Temporal and rate
  codes co-exist in the spike train and such multiplexed neural code-carryi
 ng spike trains have been shown to be spatially synchronized in multiple n
 eurons across different cortical layers during sensory information process
 ing. Inhibition is suggested to promote such synchronization\, but it is u
 nclear whether distinct subtypes of interneurons make different contributi
 ons in the synchronization of multiplexed neural codes. To test this\, in 
 vivo single-unit recordings from barrel cortex were combined with optogene
 tic manipulations to determine the contributions of parvalbumin (PV)- and 
 somatostatin (SST)-positive interneurons to synchronization of precisely t
 imed spike sequences. We found that PV interneurons preferentially promote
  the synchronization of spike times when instantaneous firing rates are lo
 w (<12 Hz)\, whereas SST interneurons preferentially promote the synchroni
 zation of spike times when instantaneous firing rates are high (>12 Hz). F
 urthermore\, using a computational model\, we demonstrate that these effec
 ts can be explained by PV and SST interneurons having preferential contrib
 ution to feedforward and feedback inhibition\, respectively. Overall\, the
 se results show that PV and SST interneurons have distinct frequency (rate
  code)-selective roles in dynamically gating the synchronization of spike 
 times (temporal code) through preferentially recruiting feedforward and fe
 edback inhibitory circuit motifs. The inhibitory neural circuit mechanisms
  we uncovered here his may have critical roles in regulating neural code-b
 ased somatosensory information processing in the neocortex. 
LOCATION:Online\, ISTA
ORGANIZER:
SUMMARY:Jeehyun Kwag: Inhibitory neural circuit mechanisms underlying neura
 l coding of sensory information in the neocortex
URL:https://talks-calendar.ista.ac.at/events/3062
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