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DTSTAMP:20260404T015815Z
UID:1613743200@ist.ac.at
DTSTART:20210219T150000
DTEND:20210219T160000
DESCRIPTION:Speaker: Inna Slutsky\nhosted by Chaitanya Chintaluri\nAbstract
 : Neural circuit functions are stabilized by homeostatic mechanisms at lon
 g timescales in response to changes in experience and learning. However\, 
 we still do not know which specific physiological variables are being stab
 ilized\, nor which cellular or neural-network components comprise the home
 ostatic machinery. At this point\, most evidence suggests that the distrib
 ution of firing rates amongst neurons in a brain circuit is the key variab
 le that is maintained around a circuit-specific set-point value in a proce
 ss called firing rate homeostasis. Here\, I will discuss our recent findin
 gs that implicate mitochondria as a central player in mediating firing rat
 e homeostasis and its impairments. While mitochondria are known to regulat
 e neuronal variables such as synaptic vesicle release or intracellular cal
 cium concentration\, we searched for the mitochondrial signaling pathways 
 that are essential for homeostatic regulation of firing rates. We utilize 
 basic concepts of control theory to build a framework for classifying poss
 ible components of the homeostatic machinery in neural networks. This fram
 ework may facilitate the identification of new homeostatic pathways whose 
 malfunctions drive instability of neural circuits in distinct brain disord
 ers.
LOCATION:Online\, ISTA
ORGANIZER:
SUMMARY:Inna Slutsky: Firing Homeostasis in Neural Circuits: From Basic Pri
 nciples to Malfunctions
URL:https://talks-calendar.ista.ac.at/events/3061
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