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DTSTAMP:20260405T162400Z
UID:1618840800@ist.ac.at
DTSTART:20210419T160000
DTEND:20210419T170000
DESCRIPTION:Speaker: Wade Regehr\nhosted by Peter Jonas\nAbstract: The cere
 bellum is a well-studied brain structure with diverse roles in motor learn
 ing\, coordination\, and cognition. We have used high-throughput transcrip
 tional profiling to provide a complete inventory of neuron types in the ce
 rebellar cortex. We have used a combination of molecular approaches\, elec
 trophysiology\, and serial electron microscopy to provide insights into th
 ese circuit elements. I will focus on three new findings.  • Surprisin
 gly\, we found that there are two molecularly distinct types of molecular 
 layer interneurons (that did not correspond to stellate cells and basket c
 ells). They have marked differences in their spontaneous firing\, excitabi
 lity\, and electrical coupling\, and appear to have distinct functional ro
 les.• Candelabrum cells (CCs) are enigmatic interneurons of the cerebell
 ar cortex that had been identified solely by their morphology. We find tha
 t CCs are a distinct cell type\, and that cerebellar inputs\, outputs and 
 local signals all converge onto CCs to allow them to assume a unique role 
 in controlling cerebellar output.• Unipolar brush cells are an interneur
 on population that was previously subdivided into two discrete populations
  that transform brief synaptic inputs into either long-lasting increases o
 r decreases in firing.  In contrast\, we find that there is continuous va
 riation in gene expression and in metabotropic signaling that generates a 
 stable cell-autonomous basis for temporal integration and learning over mu
 ltiple time scales.
LOCATION:Online\, ISTA
ORGANIZER:arinya.eller@ist.ac.at
SUMMARY:Wade Regehr: New insights into cell types and circuitry of the cere
 bellar cortex
URL:https://talks-calendar.ista.ac.at/events/3053
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