BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20210328T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20201025T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260406T074848Z
UID:1608039000@ist.ac.at
DTSTART:20201215T143000
DTEND:20201215T183000
DESCRIPTION:Speaker: Elizabeth A. Heller\nhosted by Nicole Amberg \, Lora S
 weeney\nAbstract: The Heller Lab studies the epigenetic mechanisms that un
 derlie aberrant neuronal function and behavior in neuropsychiatric disease
 . To approach this problem\, we apply preclinical mouse paradigms of drug 
 addiction and depression to determine functionally relevant histone modifi
 cations. Because the syndromes of addiction and depression persist long af
 ter cessation of the harmful experience\, stable epigenetic remodeling is 
 an attractive mechanism for such long-lasting effects and presents an intr
 iguing target for therapeutic intervention. We use high-throughput sequenc
 ing and bioinformatic approaches\, including machine learning\, to identif
 y genes at which drug- or stress-regulation of the epigenome correlates wi
 th changes in gene expression. Using novel epigenetic editing tools\, we t
 hen target individual modifications and examine their causal relevance to 
 transcription and behavior. This bottom-up approach allows direct elucidat
 ion of the causal relevance of epigenetic remodeling in the brain.
LOCATION:online\, ISTA
ORGANIZER:sandra.landauer@ist.ac.at
SUMMARY:Elizabeth A. Heller: Targeted epigenetic editing for the study of r
 eward pathophysiology 
URL:https://talks-calendar.ista.ac.at/events/2992
END:VEVENT
END:VCALENDAR