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DTSTAMP:20260406T041115Z
UID:1607695200@ist.ac.at
DTSTART:20201211T150000
DTEND:20201211T160000
DESCRIPTION:Speaker: Ioana Carcea\nhosted by Tim Vogels\nAbstract: Maternal
  care is profoundly important for mammalian survival\, and in many species
  requires the contribution of non-biological parents\, or alloparents. In 
 the absence of partum and post-partum related hormonal changes\,  allopar
 ents acquire maternal skills from experience\, by yet unknown mechanisms. 
 One critical molecular signal for maternal behavior is oxytocin\, a hormon
 e centrally released by hypothalamic paraventricular nucleus (PVN).  Do 
 experiences that induce maternal behavior act by engaging PVN oxytocin ne
 urons? To answer this\, we used virgin female mice\, animals that in the w
 ild live in colonies with experienced mothers and their pups\, helping wit
 h pup care.  We replicated this setup in the lab\, and we continuously mo
 nitored homecage behavior of virgin mice co-housed for days with a mother 
 and litter\, synchronized with recordings from virgin PVN cells\, includin
 g from oxytocin neurons. Mothers engaged virgins in maternal care in part 
 by shepherding virgins towards the nest\, ensuring their proximity to pups
 \, and in part by self-generating pup retrieval episodes\, demonstrating m
 aternal behavior to virgins. The frequency of shepherding and of dam retri
 evals correlates with virgin's subsequent ability to retrieve pups\, a qui
 ntessential mouse maternal skill. These social interactions activated virg
 in PVN and gated behaviorally-relevant cortical plasticity for pup vocaliz
 ations. Thus\, rodents can acquire maternal behavior by social transmissio
 n\, and our results describe a mechanism for adapting brains of adult care
 givers to infant needs via endogenous oxytocin. 
LOCATION:Online\, ISTA
ORGANIZER:
SUMMARY:Ioana Carcea: Social transmission of maternal behavior
URL:https://talks-calendar.ista.ac.at/events/2984
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