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DTSTART:20210328T030000
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BEGIN:VEVENT
DTSTAMP:20260405T192515Z
UID:1604408400@ist.ac.at
DTSTART:20201103T140000
DTEND:20201103T163000
DESCRIPTION:Speaker: Jessica Gaspar\nhosted by Lora Sweeney\nAbstract: Pero
 xisome proliferator-activated receptors (PPARs) are nuclear receptors that
  modulate pain\, anxiety\, and cognition. However\, their role in pain-fea
 r/anxiety interactions is unknown. In the present project\, we explored th
 e hypothesis that PPARs modulate innate anxiety responses and mnemonic fun
 ction by examining the effects of intraperitoneal administration of GW6471
  (PPAR antagonist)\, GSK0660 (PPAR antagonist)\, GW9662 (PPAR antagonist)\
 , and PEA on the elevated plus maze (EPM)\, open field (OF)\, light-dark b
 ox (LDB)\, and novel object recognition (NOR) tests in rats. Additionally\
 , because of the impact of pain on anxiety and cognitive responses\, a pos
 sible differential effect of the drugs depending on the presence or absenc
 e of chronic inflammatory pain induced by intra-plantar injection of Compl
 ete Freunds Adjuvant (CFA) was also considered. The results indicate a mod
 ulatory effect of chronic inflammatory pain on cognitive processing\, but 
 not on innate anxiety-related responses. Moreover\, in the presence of chr
 onic inflammatory pain\, blockade of PPAR impaired spatial memory and tend
 ed to increase anxiety-related responses in the LDB test. PPAR and PPAR bl
 ockade nor PEA did not modulate cognition or anxiety\, either in the prese
 nce or in the absence of pain. The blockade or activation of these recepto
 rs does not appear to modulate mechanical allodynia evoked by CFA injectio
 n.
LOCATION:online\, ISTA
ORGANIZER:sandra.landauer@ist.ac.at
SUMMARY:Jessica Gaspar: Regulation of anxiety\, and cognition in the presen
 ce or absence of pain by peroxisome proliferator-activated receptors (PPAR
 s)
URL:https://talks-calendar.ista.ac.at/events/2947
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