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DTSTART:20170326T030000
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DTSTART:20161030T020000
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DTSTAMP:20260428T111128Z
UID:589195a6bf0ad832633574@ist.ac.at
DTSTART:20170227T094500
DTEND:20170227T104500
DESCRIPTION:Speaker: Nicholas Taylor\nAbstract: Bacterial viruses\, or bact
 eriophages\, are the most abundant biological entities on the planet. Duri
 ng their infection process\, the most complex bacteriophages use a large\,
  contractile tail structure to inject their genome into the host cell. Con
 traction of the tail is regulated by the baseplate\, the tail’s most comp
 licated structure\, although it has not been understood how this is done.\
 nIn order to answer this question\, we have solved the structure of the 6-
 MDa baseplate of bacteriophage T4 in its pre- and post-host attachment sta
 tes using cryo-electron microscopy\, at a resolution of 4.1 and 6.8 Å\, r
 espectively. Our results show not only the complete organization of the ba
 seplate in near-atomic detail\, but also the transformation it undergoes u
 pon attachment. Furthermore\, we have proposed a minimal set of proteins r
 equired for all contractile injections systems\, including the type VI sec
 retion system and the R-type pyocin. Finally\, we have constructed a pseud
 o-atomic model of the complete\, 20-MDa bacteriophage T4 tail structure in
  its pre- and post-contraction states\, revealing how attachment to the ho
 st cell can initiate contraction of the tail sheath.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:pdelreal@ist.ac.at
SUMMARY:Nicholas Taylor: Structural insights into the triggering of a bacte
 riophage genome injection device
URL:https://talks-calendar.ista.ac.at/events/294
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