BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20200329T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20201025T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260404T063942Z
UID:1603195200@ist.ac.at
DTSTART:20201020T140000
DTEND:20201020T150000
DESCRIPTION:Speaker: Mateusz Sikora\nhosted by Leonid Sazanov\nAbstract: Se
 vere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) spike protein m
 ediates viral entry to the host cells and initiates the infection. As the 
 only exposed surface protein\, it is a primary target for vaccine developm
 ent. We combined cryo-electron tomography\, subtomogram averaging\, and mo
 lecular dynamics simulations to visualise and structurally characterise sp
 ike proteins on the surface of intact virions. We discover three hinges in
  the stalk of S protein that endow it with surprising flexibility and can 
 be relevant in the process of binding to the surface of the host cell. 
LOCATION:via Zoom\, ISTA
ORGANIZER:
SUMMARY:Mateusz Sikora: Towards quantitative structural cell biology: in si
 tu experiments and simulations discover flexible hinges in SARS-CoV-2 Spik
 e protein.
URL:https://talks-calendar.ista.ac.at/events/2891
END:VEVENT
END:VCALENDAR