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DTSTAMP:20260404T110256Z
UID:5f3d3f4e53965088792516@ist.ac.at
DTSTART:20200820T150000
DTEND:20200820T160000
DESCRIPTION:Speaker: Marco Sancandi\nhosted by Lora Sweeney\nAbstract: The 
 symptomatology of Parkinsons disease (PD) consists of motor and non-motors
 ymptoms (NMSs). The latter has been linked to a loss of neurotransmitters 
 other thandopamine and it has been shown to be modulated by treatments tha
 t do not act directlyon the dopaminergic system\, such as the glucagon-lik
 e peptide-1 receptor agonistexendin-4 (EX-4). Nevertheless\, the aetiology
  of NMs\, alongside with their potentialtreatments\, has yet to be fully i
 nvestigated. Recently\, using injections of theneurotoxins N--N-ethyl-2-br
 omobenzylamine (DSP-4) and 6-hydroxydopamine (6-OHDA)\, we developed a rat
  model of pre-motor PD that displays NMSs in the absenceof motor symptoms.
  Taking advantage of this model\, the effect of partial noradrenergicand d
 opaminergic denervation in several brain regions within the olfactory path
 waywas investigated using immunohistochemical and electrophysiological tec
 hniques.Neuroinflammation was observed in the primary olfactory cortex\, a
 nd the combineddenervation led to a reduction in the expression of interne
 uronal calcium bindingproteins in both the primary olfactory cortex and th
 e prefrontal cortex. On the contrary\,calcium binding proteins expression 
 in the olfactory bulbs was found to be increased\,alongside with dopaminer
 gic expression. Electrophysiologically\, neurones recordedintracellularly 
 in layer II-III of the primary olfactory cortex from the model exhibitedab
 normal prolonged epileptiform-like depolarizing postsynaptic potentials on
  localelectrical stimulation of lateral olfactory tract (LOT) afferent fib
 ers. Both structural andelectrophysiological changes were partially preven
 ted following treatment with EX-4.This rat model of pre-motor PD offers a 
 useful means for research into early diagnosisas well as early interventio
 n of PD\, possibly resulting in a delay of disease progressiontogether wit
 h improved patients quality life.
LOCATION:Foyer seminar room Ground floor / Office Bldg West (I21.EG.128)\, 
 ISTA
ORGANIZER:slandaue@ist.ac.at
SUMMARY:Marco Sancandi: Exploring the aetiology and treatment of hyposmia i
 n a rat model of pre-motor Parkinson's disease
URL:https://talks-calendar.ista.ac.at/events/2851
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