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DTSTART:20200329T030000
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DTSTAMP:20260405T023005Z
UID:5f36653f2dcef966075483@ist.ac.at
DTSTART:20200817T103000
DTEND:20200817T130000
DESCRIPTION:Speaker: Clara Becker\nhosted by Lora Sweeney\nAbstract: Balanc
 ing the relative growth of body and organs is of key importance for coordi
 nating size and function. This is of particular relevance in postembryonic
 ally growing organisms\, facing this challenge life-long. We addressed thi
 s question in the neuroretina of medaka fish (Oryzias latipes)\, where gro
 wth and size regulation are crucial for functional homeostasis of the visu
 al system. We find that a central growth regulator\, insulin-like growth f
 actor 1 receptor (Igf1r)\, is necessary and sufficient for proliferation c
 ontrol in the postembryonic retinal stem cell niche\, the ciliary marginal
  zone (CMZ). Targeted activation of Igf1r signaling in the CMZ uncouples n
 euroretina growth from body size control\, increasing layer thickness whil
 e preserving the structural integrity of the retina. The retinal expansion
  is driven exclusively by enhanced proliferation of progenitor cells while
  stem cells do not respond to Igf1r modulation. Our findings position Igf 
 signaling as key module controlling retinal size and structure with evolut
 ionary implications.
LOCATION:Heinzel Seminar Room / Office Bldg West (I21.EG.101)\, ISTA
ORGANIZER:slandaue@ist.ac.at
SUMMARY:Clara Becker: Igf signaling coordinates retina growth with body siz
 e by regulating retinal progenitor proliferation
URL:https://talks-calendar.ista.ac.at/events/2850
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