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DTSTART:20200329T030000
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BEGIN:VEVENT
DTSTAMP:20260405T192513Z
UID:1597050000@ist.ac.at
DTSTART:20200810T110000
DTEND:20200810T120000
DESCRIPTION:Speaker: Sourabh Bhide\nhosted by Carl-Philipp Heisenberg\nAbst
 ract: The intrinsic genetic programme of a cell\, combined with biochemic
 al signals received from the environment\, is not always sufficient to ex
 plain the cell’s activities. Instead\, mechanical properties of the env
 ironment and mechanical stimuli are increasingly being recognized as dete
 rminants of a cell’s behavior. In the epithelial folding event that con
 stitutes the beginning of gastrulation in Drosophila\, and specifically o
 f the invagination of the mesodermal primordium\, the genetic programme o
 f the future mesoderm leads to the establishment of a contractile actomyo
 sin network that triggers apical constriction of cells\, and thereby\, f
 urrow formation. However\, some cells do not constrict but instead stretc
 h\, even though they share the same genetic programme as their constricti
 ng neighbours. We show here that their behaviour is not determined only 
 by their genetic programme\, but also by tissue-wide interactions. Being 
 passively stretched by contracting neighbours prevents constriction even
  when an otherwise sufficient amount of apical\, active actomyosin has b
 een accumulated.
LOCATION:https://istaustria.zoom.us/j/6036991352?pwd=Ung4b2ZGU2h5NE1INE1tWT
 BjNTdiUT09\, ISTA
ORGANIZER:alexandra.mally@ist.ac.at
SUMMARY:Sourabh Bhide: Cell-cell mechanical interactions reinterpret develo
 pmental patterning during epithelial folding in Drosophila embryo
URL:https://talks-calendar.ista.ac.at/events/2849
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