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DTSTART:20170326T030000
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DTSTART:20161030T020000
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DTSTAMP:20260428T233023Z
UID:58876568a5037040773891@ist.ac.at
DTSTART:20170213T084500
DTEND:20170213T094500
DESCRIPTION:Speaker: Lars Plate\nAbstract: Amyloid diseases are characteriz
 ed by the extracellular aggregation and deposition of misfolding-prone pro
 teins\, which leads to tissue degeneration. Few general therapeutic strate
 gies exist to treat amyloid diseases due to the large variation in disease
 -associated amyloidogenic proteins as well as the range of impacted tissue
 . Here\, I describe a broadly applicable approach for treatment by targeti
 ng endogenous protein quality control pathways in the cells producing the 
 amyloidogenic proteins. Preferential reprogramming of the ER proteostasis 
 network through activation of the Unfolded Protein Response-associated tra
 nscription factor ATF6 attenuates the secretion and extracellular aggregat
 ion of structurally-distinct amyloidogenic proteins. This seminar will als
 o describe mechanistic insights into how preferential remodeling of the ER
  proteostasis network can influence the quality control decisions for dest
 abilized proteins through and altering engagement of chaperones and qualit
 y control factors. Finally\, I will discuss the identification and charact
 erization of first-generation small molecule activators of the ATF6 transc
 riptional program\, focusing specifically on their mechanism of action\, a
 s well as their impact on proteostasis of the endogenous proteome and dise
 ase-associated amyloidogenic proteins.
LOCATION:Seminar room Big Ground floor / Office Bldg West (I21.EG.101)\, IS
 TA
ORGANIZER:pdelreal@ist.ac.at
SUMMARY:Lars Plate: Targeting Proteostasis to Treat Amyloid Diseases
URL:https://talks-calendar.ista.ac.at/events/284
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