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DTSTART:20170326T030000
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DTSTART:20161030T020000
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DTSTAMP:20260428T072823Z
UID:5875ecb5c47b0204021321@ist.ac.at
DTSTART:20170220T160000
DTEND:20170220T170000
DESCRIPTION:Speaker: Karol Fiedorczuk and James Letts\nhosted by Leonid Saz
 anov\nAbstract: Structural studies of the ovine mitochondrial electron tra
 nsport chain: First atomic structure of complex I and the architecture of 
 respiratory supercomplexes\n\nCellular energy metabolism is mainly carried
  out in the double membrane organelle known as the mitochondria. The mitoc
 hondrial oxidative phosphorylation electron transport chain (OXPHOS-ETC) i
 s made up of five large membrane protein complexes (CI-CV) in the inner mi
 tochondrial membrane and is responsible for the majority of cellular ATP s
 ynthesis. ATP is a energy rich small molecule known as the "energy currenc
 y of the cell" and is used throughout the cell to power many fundamental r
 eactions. Of the five complexes CI is the largest (~1 MDa\, 45 subunits) a
 nd remains the least well structurally and mechanistically characterized. 
 Here we present the first fully-assigned nearly all-atomic 3.9 Å structur
 e of CI from sheep heart mitochondria\, solved by cryo-EM. Additionally\, 
 it is known that the OXPHOS-ETC complexes come together to form supercompl
 exes (SCs) of defined stoichiometry. We also present here two distinct arc
 hitectures of SCs I+III2+IV\, containing all subunits required to pass ele
 ctrons from NADH to molecular oxygen (O2)\, as well as an architecture of 
 SC I+III2.\n
LOCATION:Raiffeisen Lecture Hall\, Central Building\, ISTA
ORGANIZER:pdelreal@ist.ac.at
SUMMARY:Karol Fiedorczuk and James Letts: IST Austria Award Lecture
URL:https://talks-calendar.ista.ac.at/events/280
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