BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20170326T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20161030T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260428T233019Z
UID:5885c85f418e3875894402@ist.ac.at
DTSTART:20170215T084500
DTEND:20170215T094500
DESCRIPTION:Speaker: Francesca Santoro\nAbstract: In recent years\, 3D nano
  and micro-fabricated platforms have been used for multiple in vitro biome
 dical applications. In particular\, 3D conductive nano and microstructures
  can be used as sensing elements of biological phenomena revealed as volta
 ge or current changes\, such as action potentials as well as outgrowth top
 ological cues. Traditional devices are planar\, and a cleft between cells 
 and device typically forms\, affecting the recorded/stimulating signal qua
 lity. Devices with protruding 3D nanostructures have been proven to be tig
 htly connected to in vitro populations of electrogenic cells\, showing bet
 ter signal recording/stimulating performances than planar devices(1-6).\nH
 ere\, I will show surface 3D modifications of metal-based materials as wel
 l as conductive polymers for cell-chip coupling. First\, I will present an
  innovative technique based on correlative scanning electron microscopy (S
 EM) and focused ion beam (FIB) spatially controlled sectioning to resolve 
 cellular ultrastructures at the cell-chip interface with 10 nm resolution 
 applicable to any organic/inorganic material interacting with individual a
 dherent cells. The understanding of the contact area between cells and nan
 oelectrodes represents the first step for an optimal design of chip-based 
 devices. In fact\, I will show that 3D nanopillar-like electrodes induce t
 he cell membrane to wrap more tightly than in case of planar electrodes. T
 aking advantage of this intimate contact\, one can use nanoelectrodes to a
 pply an electrical pulse for opening a pore at the plasma membrane such th
 at the nanoelectrode can gain intracellular access without cell’s death. 
 In this case\, multi-site non-invasive investigations of intracellular pro
 cesses can be successfully carried out.
LOCATION:Mondi Seminar Room 3\, Central Building\, ISTA
ORGANIZER:pdelreal@ist.ac.at
SUMMARY:Francesca Santoro: 3D nanostructured platforms for in vitro biomedi
 cal applications
URL:https://talks-calendar.ista.ac.at/events/279
END:VEVENT
END:VCALENDAR