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DTSTART:20170326T030000
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DTSTART:20161030T020000
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DTSTAMP:20260429T035157Z
UID:58899ffd1832f244495831@ist.ac.at
DTSTART:20170130T110000
DTEND:20170130T120000
DESCRIPTION:Speaker: Giulio Abagnale\nhosted by Johann Georg Danzl\nAbstrac
 t: Mechanical stimuli are an integrant component of the microenvironment c
 ontrolling the differentiation and self-renewal of stem cells\; nonetheles
 s\, it is still not fully understood how such cues can regulate stem cell 
 functions and drive their fate. We investigated the impact of various type
 s of groove-ridge substrates on the behavior of mesenchymal stem cells (MS
 Cs) and induced pluripotent stem cells (iPSCs). To this purpose\, we emplo
 yed different micro- and nanofabrication approaches to generate defined pa
 tterns on the surface of a plastic polymer. We then assessed how such topo
 graphic cues modulate various aspects of the biology of MSCs and iPSCs thr
 ough the use of confocal microscopy\, image analysis tools and genome wide
  gene expression profiles. Our results show that both micro- and nanogroov
 ed biomaterials induced the elongation of MSCs\, affected the size and num
 ber of focal adhesions and guided their migration. Furthermore\, specific 
 substrates were able to favor the differentiation of MSCs toward adipogeni
 c or osteogenic lineage. With regards to iPSCs\, nanostructured materials 
 elicited an increase in the aspect ratio of both single cells and colonies
  by guiding the orientation of actin fibers and the polarity of cell divis
 ion. Morphological changes of iPSCs were reflected in the spatial distribu
 tion of pluripotency markers\, moreover elongated colonies showed increase
 d differentiation upon BMP4 treatment. Finally\, we elucidated the role th
 at mechanotransducers like YAP and TAZ play in mediating these phenotypes 
 and described novel shuttling dynamics and molecular interactions of such 
 transcription factors. Taken together these findings shed new light on how
  surface topography controls crucial molecular processes and orchestrates 
 the overall architecture of cells and tissues.
LOCATION:Meeting room 3rd floor / Lab Bldg East (I06.03.211)\, ISTA
ORGANIZER:rsix@ist.ac.at
SUMMARY:Giulio Abagnale: Impact of Topographic Stimuli on the Biology of Me
 senchymal and Induced Pluripotent S
URL:https://talks-calendar.ista.ac.at/events/277
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