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DTSTAMP:20260406T041928Z
UID:1589284800@ist.ac.at
DTSTART:20200512T140000
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DESCRIPTION:Speaker: Rafael Yuste\nhosted by Neuroscience Students and Post
 docs\nAbstract: The design of neural circuits\, with large numbers of neur
 ons interconnected in vast networks\, strongly suggest that they are speci
 fically build to generate emergent functional properties (1). To explore t
 his hypothesis\, we have developed two-photon holographic methods to selec
 tive image and manipulate the activity of neuronal populations in 3D in vi
 vo (2). Using them we find that groups of synchronous neurons (neuronal en
 sembles) dominate the evoked and spontaneous activity of mouse primary vis
 ual cortex (3). Ensembles can be optogenetically imprinted for several day
 s and some of their neurons trigger the entire ensemble (4). By activating
  these pattern completion cells in ensembles involved in visual discrimina
 tion paradigms\, we can bi-directionally alter behavioral choices (5).  O
 ur results demonstrate that ensembles are necessary and sufficient for vis
 ual perception and are consistent with the possibility that neuronal ensem
 bles are the functional building blocks of cortical circuits. 1.    R.
  Yuste\, From the neuron doctrine to neural networks. Nat Rev Neurosci 16\
 , 487-497 (2015).2.    L. Carrillo-Reid\, W. Yang\, J. E. Kang Miller\,
  D. S. Peterka\, R. Yuste\, Imaging and Optically Manipulating Neuronal En
 sembles. Annu Rev Biophys\,  46: 271-293 (2017). 3.    J. E. Miller\,
  I. Ayzenshtat\, L. Carrillo-Reid\, R. Yuste\, Visual stimuli recruit intr
 insically generated cortical ensembles. Proceedings of the National Academ
 y of Sciences of the United States of America 111\, E4053-4061 (2014).4. 
    L. Carrillo-Reid\, W. Yang\, Y. Bando\, D. S. Peterka\, R. Yuste\, Im
 printing and recalling cortical ensembles. Science 353\, 691-694 (2016).5.
     L. Carrillo-Reid\, S. Han\, W. Yang\, A. Akrouh\, R. Yuste\, (2019)
 . Controlling visually-guided behavior by holographic recalling of cortica
 l ensembles. Cell 178\, 447-457. DOI:https://doi.org/10.1016/j.cell.2019.0
 5.045.
LOCATION:https://istaustria.zoom.us/j/99213372643?pwd=TjQvRDhzTUZnQkQwM0p0b
 ld4c1BPUT09\, ISTA
ORGANIZER:rita.six@ist.ac.at
SUMMARY:Rafael Yuste: Neuroscience Seminar Series - Rafael Yuste
URL:https://talks-calendar.ista.ac.at/events/2764
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