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DTSTART:20170326T030000
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DTSTAMP:20260428T144336Z
UID:5886fdf1ac166516303413@ist.ac.at
DTSTART:20170203T110000
DTEND:20170203T120000
DESCRIPTION:Speaker: Anton Sumser\nhosted by Maximilian Jösch\nAbstract: S
 ensory processing is mostly considered to be a function of the cerebral co
 rtex\, following low level precortical signal transformations. However\, t
 he cortex is not the endpoint of neuronal processing\, but rather a hub of
  extensive cortico-cortical and cortico-subcortical networks. A major cort
 ical output pathway originates in ‘thick-tufted’ neurons in cortical lay
 er 5B and is characterized by uniquely strong ‘driver’ connections to su
 bcortical areas\, especially (‘higher-order’) thalamus. Higher-order tha
 lamus in turn projects mostly to cortical areas\, thereby constituting cor
 tico-thalamo-cortical loops. However\, the functions of these cortico-thal
 amic networks are mostly unknown. Using the mouse whisker system as a mode
 l\, we characterized the organization and dynamics of the pathway’s major
  input from cortical layer 5B.\n\nWe first asked if the well-ordered body 
 representation in the primary somatosensory ‘barrel’ cortex is maintaine
 d along the cortico-thalamic pathway. Using quantitative neuronal tract tr
 acing techniques we found that L5B innervation of thalamus is dense\, low 
 in numbers and indeed topographic. Interestingly\, the cortical whisker ma
 p is quadrupled in thalamus. Next\, we characterized the in vivo dynamics 
 of the cortico-thalamic driver pathway with electrophysiology and optogene
 tics in anesthetized mice. We found reliable signal transmission that is h
 owever strongly regulated by slow cortical activity rhythms (‘up and down
  states’). Surprisingly\, whisker deflection signals reach higher-order t
 halamus nearly exclusively via the cortico-thalamic driver pathway\, inver
 ting the view of the thalamus as a gateway to cortex. In awake behaving an
 imals\, higher-order thalamus is also highly dependent on cortical inputs 
 and might functionally serve to discriminate between unexpected and expect
 ed sensory signals.
LOCATION:Meeting room 1st floor  / Lab Bldg East (I06.01.406)\, ISTA
ORGANIZER:rsix@ist.ac.at
SUMMARY:Anton Sumser: The Corticothalamic Driver Pathway in the Mouse Whisk
 er System
URL:https://talks-calendar.ista.ac.at/events/275
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