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DTSTART:20200329T030000
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DTSTAMP:20260403T220453Z
UID:5e147ca6ed5ab519165745@ist.ac.at
DTSTART:20200505T140000
DTEND:20200505T150000
DESCRIPTION:Speaker: Jernej Ule\nhosted by Mario De Bono\nAbstract: I will 
 discuss the molecular elements that control the assembly and function of R
 NPs in development and disease. In particularly\, I will present our new f
 indings into the role of RNA structure in RNP assembly. We focused on Stau
 fen proteins\, which contain multiple domains that bind to double-stranded
  RNA regions\, formed predominantly through base-pairing complementarity. 
 We determined an atlas of RNA secondary structures that are bound by STAU1
  & STAU2 in neurons using hiCLIP (RNA hybrid individual nucleotide resolut
 ion crosslinking and immunoprecipitation). We identified hundreds of thous
 ands of stable RNA secondary structures that are enriched in synaptically 
 localised transcripts. Notably\, we observed patterns of dense RNA-RNA con
 tacts that reflect the formation of topologically associating domains (RNA
 -TADs) on long 3UTRs\, which are regulated throughout development and are 
 linked to the binding of sequence-specific RBPs. Our evidence points towar
 ds a working model where RNA-structure dependent compaction of long 3UTRs 
 organises multi-protein RNP assembly in Staufen-containing granules to med
 iate neuronal RNA localisation.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:abonvent@ist.ac.at
SUMMARY:Jernej Ule: RNA structure-mediated RNP assembly for neuronal mRNA l
 ocalisation
URL:https://talks-calendar.ista.ac.at/events/2716
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