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DTSTART:20210328T030000
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DTSTAMP:20260405T022922Z
UID:1610960400@ist.ac.at
DTSTART:20210118T100000
DTEND:20210118T110000
DESCRIPTION:Speaker: Rong Li\nhosted by Carl-Philipp Heisenberg\nAbstract: 
 Meiotic maturation and fertilization of mammalian oocytes involve two roun
 ds of asymmetric cell divisions generating a large fertilized egg and two 
 small polar bodies. The position and orientation of meiotic spindles are c
 ritical for the success of these divisions. The chromatin and multiple act
 in assemblies play keys roles in these processes. Spindle migration and ex
 trusion of the first polar body is accomplished through a symmetry breakin
 g process involving formin-nucleated actin and dynamic organelle rearrange
 ments. Once the chromatin is positioned subcortically the Arp2/3 complex i
 s activated by the cortex-proximal meiotic chromatin through Ran GTPase si
 gnaling. The Arp2/3 complex nucleated actin network powers a cytoplasmic f
 low that pushes the spindle and chromosome toward the cortex. It also serv
 es to restrict myosin-II-driven cortical contraction\, which generates an 
 opposite force moving the meiotic spindle/chromatin toward oocyte interior
 . During meiosis II\, polarization of the two opposing forces provide the 
 torque driving the spindle rotation required for the second meiotic divisi
 on. These dynamic processes are likely targets of the aging process durin
 g female reproductive decline.
LOCATION:Raiffeisen Lecture Hall\, ISTA
ORGANIZER:arinya.eller@ist.ac.at
SUMMARY:Rong Li: Actin-based forces in asymmetric meiotic cell division
URL:https://talks-calendar.ista.ac.at/events/2707
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