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DTSTART:20200329T030000
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DTSTART:20191027T020000
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DTSTAMP:20260404T020007Z
UID:5e1dbaf5e4f29518075351@ist.ac.at
DTSTART:20200317T090000
DTEND:20200317T100000
DESCRIPTION:Speaker: Nikolaos Konstantinides\nhosted by Max Jösch\nAbstrac
 t: Transcription factors regulate the molecular\, morphological\, and phys
 iological characters of neurons and are responsible for their impressive c
 ell type diversity. We used single-cell sequencing to access the transcrip
 tomes of all neurons in the Drosophila optic lobes and used machine learni
 ng to identify transcription factors that regulate neurotransmitter identi
 ty\, which we verified genetically. We showed that the same terminal chara
 cters are regulated by different transcription factors in different cell t
 ypes\, arguing for extensive phenotypic convergence. We found that neurotr
 ansmitter identity is established days earlier than it is being implemente
 d. To understand the first steps of neuronal identity acquisition\, we seq
 uenced young and old neurons during larval stages and established a timeli
 ne of expression of the different effector gene modules. We are also compa
 ring the cell type composition in the brains of different insects to under
 stand how neuronal diversity evolves.Collectively\, our data provide a dee
 p understanding of the developmental and functional specification of a com
 plex brain structure and testable hypotheses about its evolutionary histor
 y.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:tguggenb@ist.ac.at
SUMMARY:Nikolaos Konstantinides: Evolution and development of neuronal dive
 rsity in the Drosophila optic lobes
URL:https://talks-calendar.ista.ac.at/events/2688
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