BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20200329T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20191027T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260405T192111Z
UID:5e1d952864d30121482760@ist.ac.at
DTSTART:20200309T090000
DTEND:20200309T100000
DESCRIPTION:Speaker: Bruno diStefano\nhosted by Gaia Novarino\nAbstract: Po
 st-transcriptional mechanisms have the potential to influence complex chan
 ges in gene expression\, yet their role in regulating stem cell potency an
 d cell fate transitions remain largely unexplored. We have recently identi
 fied the RNA processing protein NUDT21 as a key factor that restricts cell
  identity by modulating the alternative polyadenylation of mRNAs encoding 
 chromatin regulators. In addition\, through systematic characterization of
  primed and nave human embryonic stem cells\, we have uncovered an unexpec
 ted sensitivity of nave pluripotent stem cells to MAPK signal inhibition\,
  which affects their proliferation rate\, survival and genome integrity. F
 inally\, we have demonstrated that the RNA helicase DDX6 acts as a key reg
 ulator of mammalian cell fate through its control of P-body assembly in bo
 th pluripotent stem cells and adult progenitor populations.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:tguggenb@ist.ac.at
SUMMARY:Bruno diStefano: Dissecting mechanisms that govern cellular plastic
 ity
URL:https://talks-calendar.ista.ac.at/events/2676
END:VEVENT
END:VCALENDAR