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DTSTART:20191027T020000
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DTSTAMP:20260404T030800Z
UID:5e1d97a3a56e4759292983@ist.ac.at
DTSTART:20200310T090000
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DESCRIPTION:Speaker: Benjamin Stauch\nhosted by Carrie Bernecky\nAbstract: 
 G protein-coupled receptors (GPCRs) are transmembrane proteins with partic
 ular relevance in disease and physiology\, and privileged drug targets. Ov
 er the past 20 years\, advances in crystallography and more recently\, cry
 o electron microscopy have provided a wealth of structural information on 
 GPCRs. Melatonin receptors MT1 and MT2 are GPCRs that in mammals establish
  circadian rhythm in sync with environmental light-dark cues. Jet lag\, sh
 ift work and artificial lighting can disrupt a natural rhythm and cause he
 alth problems. I will present X-ray free-electron laser structures of MT1 
 and MT2\, determinants for their selective and specific ligand recognition
  and highly unusual ligand access through a membrane-buried lateral pore. 
 Further\, I demonstrate the structure-based design of MT1-selective ligand
 s with novel in vivo efficacy that allow to interrogate the melatonin syst
 em chemically and provide a template for future melatonergic therapeutics.
 Stauch & Johansson et al. (2019). Nature\, doi: 10.1038/s41586-019-1141-3J
 ohansson & Stauch et al. (2019). Nature\, doi: 10.1038/s41586-019-1144-0St
 ein et al. (2020). Nature\, doi: 10.1038/s41586-020-2027-0
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:tguggenb@ist.ac.at
SUMMARY:Benjamin Stauch: Structural biology of melatonin receptors
URL:https://talks-calendar.ista.ac.at/events/2674
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