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DTSTART:20200329T030000
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DTSTART:20191027T020000
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DTSTAMP:20260404T004608Z
UID:5e3c030a5a355578100772@ist.ac.at
DTSTART:20200210T110000
DTEND:20200210T120000
DESCRIPTION:Speaker: David Mörsdorf\nhosted by Martin Loose\nAbstract: Ext
 racellular signaling molecules coordinate early embryonic development. In 
 zebrafish\, the secreted Nodal signaling proteins were proposed to functio
 n as classical morphogens that disperse from a localized source to control
  the development of distant cells. However\, recent findings suggest that 
 Nodals may not move over a distance and instead signal mainly to neighbori
 ng cells which\, due to Nodal auto-induction\, relay the signal to distant
  cells. I will present experiments performed in zebrafish embryos in which
  I directly test these two models of Nodal signaling and my efforts to unv
 eil the mechanisms of Nodal dispersal.First\, I assessed the endogenous No
 dal signaling range in transplantation experiments and tested whether Noda
 l dispersal requires a relay mechanism. Second\, I established that the di
 ffusion of extracellular proteins can be tuned with membrane tethers. Usin
 g these tethers as tools\, I found that the high diffusivity of Leftys  lo
 ng-range Nodal inhibitors  is important to robustly dampen Nodal signaling
 . Third\, I wanted to reveal the molecular basis for the vastly different 
 diffusivities of the long-range Leftys and the short-range Nodals. I will 
 present my findings of co-immunoprecipitation/mass spectrometry experiment
 s to identify putative Nodal diffusion regulators that may explain the sho
 rt Nodal range. Together\, my data support a model in which zebrafish Noda
 ls disperse in the tissue to signal over short distances which is consiste
 nt with the idea that Nodal diffusion underlies embryonic tissue patternin
 g.
LOCATION:Heinzel Seminar Room / Office Bldg West (I21.EG.101)\, ISTA
ORGANIZER:sdanzing@ist.ac.at
SUMMARY:David Mörsdorf: Quantifying and perturbing the movement of extrace
 llular signaling proteins
URL:https://talks-calendar.ista.ac.at/events/2635
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