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DTSTAMP:20260404T020007Z
UID:5e09f536bbb60547011078@ist.ac.at
DTSTART:20200224T090000
DTEND:20200224T100000
DESCRIPTION:Speaker: Rashmi Priya\nhosted by Ani Kicheva\nAbstract: Embryog
 enesis entails generation of diverse cell fates and emergence of complex m
 orphogenetic patterns. A key question remains as to how morphogenesis and 
 mechanics contribute to cell fate decisions in a complex and growing organ
 . During cardiac development\, the myocardial wall transforms from a monol
 ayer to an intricate topological structure consisting of two distinct type
 s of cardiomyocytes (CMs): outer compact and inner trabecular layer CMs. T
 his process of cardiac trabeculation is crucial for cardiac function as ab
 errations lead to congenital cardiomyopathies and embryonic lethality. Yet
 \, the mechanisms underlying the emergence and specification of trabecular
  CMs remain unknown. Using the zebrafish heart in combination with high-re
 solution quantitative microscopy\, in vivo measurements of tension/subcell
 ular dynamics\, genetic mosaic tools and embryological interventions\, I n
 ow report that contractility couples morphogenesis and cell fate to ensure
  robust self-organization of CMs into compact versus trabecular layer. Pro
 liferation induced crowding triggers symmetry breaking by generating local
  differences in cellular contractility. These effects lead to stochastic d
 elamination of CMs from the outer compact layer to seed the inner trabecul
 ar layer. By manipulating contractility at the single cell-level\, I show 
 that reducing contractility abrogates delamination while inducing contract
 ility Augments delamination\, and strikingly\, inducing contractility is s
 ufficient to drive delamination even in the absence of critical trabeculat
 ion signals like Nrg/Erbb2 or blood- flow. Further\, using controlled pert
 urbations to decouple mechanical cues from biochemical signaling\, I find 
 that mechanical cues drive CM fate specification. Inducing tension heterog
 eneity (and thereby CM delamination) by manipulation of cell density or co
 ntractility is sufficient to generate differential Notch activity as well 
 as apicobasal polarity. Overall\, this study reveals how form and function
  emerge as a collective product of individual cell behaviors\, and argues 
 for a system-level approach integrating mechanics with regulatory circuits
  for a cogent understanding of multicellular organization in vivo. As part
  of my future research plans\, I will also discuss strategies to decode th
 e principles of self-organization across length scales underlying the emer
 gence of complex topological orders during organogenesis.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:tguggenb@ist.ac.at
SUMMARY:Rashmi Priya: Design Principles of Heart Morphogenesis: Forms\, For
 ces and Fate
URL:https://talks-calendar.ista.ac.at/events/2614
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