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DTSTAMP:20260404T015801Z
UID:5e2f5af0f3f38867814043@ist.ac.at
DTSTART:20200129T113000
DTEND:20200129T123000
DESCRIPTION:Speaker: Sylvain Gabriele\nhosted by Edouard Hannezo\nAbstract:
  Collective cell migration is fundamental throughout development\, during 
 wound healing and in many diseases. Although much effort has focused on ce
 ll-cell junctions\, a role for  matrix stiffness and physical confinement 
 in epithelial cell migration remains unclear. To address these open questi
 ons\, we studied first the migration of highly motile keratocytes on cultu
 re substrates with similar biochemical properties and a wide range of rigi
 dities (from kPa to GPa). We show a matrix rigidity-dependent regulation o
 f the directional persistence in motile keratocytes and our findings refin
 e the role of ?v?3 and ?5?1 integrins in the molecular clutch model. Then\
 , we used adhesive microstripes of varying widths to mimic the spatial con
 finement experienced by follower cells within epithelial tissues. Our find
 ings show a direct correlation between the migration velocity of confined 
 cells and their cell-substrate adhesive area. Closer examination revealed 
 that adhesive area confinement reduces lamellipodial protrusive forces\, d
 ecreases the number of focal complexes at the leading edge and prevents th
 e maturation of focal adhesions at the trailing edge\, together leading to
  less effective forward propelling forces. These findings demonstrate that
  epithelial confinement alone can induce follower-like behaviours and iden
 tify substrate adhesive area confinement as a key determinant of cell velo
 city in collective migration. Finally\, we will introduce recent experimen
 ts that use well-defined trains of epithelial cells to decipher the role o
 f axial and lateral adhesive interactions in collective migration of epith
 elial cells. These results suggest that the establishment of lateral adhes
 ive interactions lead to a drop of the cell migration velocity\, whereas a
 xial adhesive interactions do not affect the migration speed of epithelial
  cohorts.
LOCATION:Mondi Seminar Room 3\, Central Building\, ISTA
ORGANIZER:channezo@ist.ac.at
SUMMARY:Sylvain Gabriele: From individual motion to collective cell migrati
 on
URL:https://talks-calendar.ista.ac.at/events/2606
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