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UID:5e26ce1113b49292777770@ist.ac.at
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DESCRIPTION:Speaker: Tomás J. Ryan\nhosted by Maximilian Jösch\nAbstract:
  Over the past seven years\, memory engram technology has provided an unpr
 ecedented tool for understanding specific memory representations in the ro
 dent brain. Memory engram technology integrates immediate early gene (IEG)
  labelling techniques with optogenetics to facilitate the activity-depende
 nt tagging and reversible manipulation of components of specific memory en
 grams. Using engram technology we can ask how learning effects the plastic
 ity of engram cells\, and conversely\, how manipulation of engram cells al
 ters memory function. Thus it is now possible to study the causal relation
 ship between the isomorphic behavioral and physiological properties of mem
 ory in a unitary experimental preparation.In my talk\, I will describe the
  early development of engram technology and how it enables us to label spa
 rse populations of hippocampal cells that are both sufficient and necessar
 y for the recall of specific contextual memories (Liu et al.\, 2012\; Rami
 rez et al.\, 2013). I will then present our research on engram cell plasti
 city\, in order to demonstrate how engram technology can be applied as an 
 effective tool for progressive investigation into the neurobiology of long
 -term memory consolidation and amnesia (Ryan et al.\, 2015). I will propos
 e a novel form of engram circuit plasticity characterized by an all or non
 e engram-to-engram cell transynaptic connectivity\, which survives retrogr
 ade amnesia\, and may account for the long-term storage of learned informa
 tion at an anatomical level. I will then present more recent research on t
 he plasticity of whole engram cell intrinsic excitability as a potential m
 echanism of short-term memory (Pignatelli\, Ryan et al.\, 2018 (https://ww
 w.cell.com/neuron/fulltext/S0896-6273(18)31038-9?_returnURL=https%3A%2F%2F
 linkinghub.elsevier.com%2Fretrieve%2Fpii%2FS0896627318310389%3Fshowall%3Dt
 rue))Based on this research I will discuss a working model of how learned 
 information may be persistently stored in a distributed and hierarchical m
 emory circuit through stable engram cell connectivity patterns (Tonegawa e
 t al.\, 2015\,Queenan et al.\, 2017 (https://nyaspubs.onlinelibrary.wiley.
 com/doi/full/10.1111/nyas.13348)). I will discuss findings from my own res
 earch group that extend these findings. In particular I will discuss unpub
 lished data on the development of memory engrams across on the lifespan\, 
 and how memory engram function may be related to the evolution of innate i
 nstincts.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:rsix@ist.ac.at
SUMMARY:Tomás J. Ryan: Information Storage in Memory Engrams
URL:https://talks-calendar.ista.ac.at/events/2605
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