BEGIN:VCALENDAR
VERSION:2.0
PRODID:icalendar-ruby
CALSCALE:GREGORIAN
METHOD:PUBLISH
BEGIN:VTIMEZONE
TZID:Europe/Vienna
BEGIN:DAYLIGHT
DTSTART:20170326T030000
TZOFFSETFROM:+0100
TZOFFSETTO:+0200
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=3
TZNAME:CEST
END:DAYLIGHT
BEGIN:STANDARD
DTSTART:20161030T020000
TZOFFSETFROM:+0200
TZOFFSETTO:+0100
RRULE:FREQ=YEARLY;BYDAY=-1SU;BYMONTH=10
TZNAME:CET
END:STANDARD
END:VTIMEZONE
BEGIN:VEVENT
DTSTAMP:20260428T051941Z
UID:587e151a30718833607132@ist.ac.at
DTSTART:20170228T094500
DTEND:20170228T104500
DESCRIPTION:Speaker: Carrie Bernecky\nAbstract: RNA polymerase (Pol) II pro
 duces mRNA during transcription of protein-coding genes in all eukaryotic 
 cells. In my talk\, I will report on the 3.4 Å-resolution cryo-EM structu
 re of a mammalian Pol II elongation complex (EC). The structure reveals de
 tails of EC-nucleic acid interactions\, and yields insights into the confo
 rmational dynamics of Pol II. Upstream DNA emanates from the active center
  cleft at an angle of ~105º with respect to downstream DNA. This position
  of upstream DNA allows for binding of the general transcription elongatio
 n factor DSIF (SPT4-SPT5). Our results provide a structural basis for the 
 mechanistic analysis of human transcription elongation.
LOCATION:Seminar room Big Ground floor / Office Bldg West (I21.EG.101)\, IS
 TA
ORGANIZER:bkunes@ist.ac.at
SUMMARY:Carrie Bernecky: Structural studies of mammalian RNA polymerase II 
 elongation
URL:https://talks-calendar.ista.ac.at/events/255
END:VEVENT
END:VCALENDAR