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DTSTART:20200329T030000
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DTSTART:20191027T020000
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DTSTAMP:20260404T015958Z
UID:5e1de5be9c2bc128367895@ist.ac.at
DTSTART:20200122T150000
DTEND:20200122T160000
DESCRIPTION:Speaker: Aleksandra Galitsyna\nhosted by Fyodor Kondrashov\nAbs
 tract: The conformation of DNA in the cells of living organisms remains to
  be a puzzling problem for nowadays science. Chromatin structure\, as prob
 ed by chromosome conformation capture techniques\, is linked to various mo
 lecular functions of the cell\, including gene expression\, regulation\, a
 nd replication. Few mechanisms were discovered that contribute to the chro
 matin structure formation\, such as loop extrusion\, compartmentalization\
 , and Polycomb looping. However\, the details of these processes remain to
  be elusive. One of the sources of knowledge is a natural variability of D
 NA structure formation mechanisms across different species. The data for t
 he most informative and popular conformation capture technique\, Hi-C\, ar
 e available for an extensive number of species\, including animals\, plant
 s\, bacteria\, fungi\, and archaea. For example\, CTCF protein serves as a
  loop extrusion boundary and has a spectacular evolutionary history\, whic
 h is tightly connected to the presence of topologically associating domain
 s (TADs). Other notable discoveries are made through the analysis of time-
 course Hi-C data. For example\, analysis of embryogenesis allows for unrav
 eling the interplay between loop extrusion\, compartmentalization\, and ex
 pression. In this seminar\, we will discuss recent studies of chromatin st
 ructure in embryogenesis of Drosophila \, zebrafish\, and mammals. We will
  cover controversial problems in the field\, for example\, the causative c
 onnection between chromatin structure and gene expression\, establishment 
 of histone modifications alongside large-scale chromatin conformation. The
  seminar will provide a general introduction to the chromatin structure in
  evolution and development\, highlighting the most recent discoveries in t
 he field.
LOCATION:Mondi Seminar Room 1\, Central Building\, ISTA
ORGANIZER:alyulina@ist.ac.at
SUMMARY:Aleksandra Galitsyna: Introduction to chromatin structure in evolut
 ion and development
URL:https://talks-calendar.ista.ac.at/events/2538
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