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DTSTART:20200329T030000
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DTSTART:20191027T020000
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DTSTAMP:20260403T220406Z
UID:5d94aeb525bf2642291623@ist.ac.at
DTSTART:20200124T150000
DTEND:20200124T160000
DESCRIPTION:Speaker: Daan de Groot and Age Tjalma\nhosted by Gasper Tkacik\
 nAbstract: Many microorganisms might have been driven towards maximal grow
 th rates by natural selection. Inspired by this assumption\, we investigat
 e what a growth-maximizing microbe must look like. For this\, we first unc
 over the building blocks of self-fabrication: Elementary Growth Modes. The
 se are the minimal modes of gene expression that give rise to balanced sel
 f-fabrication. Moreover\, it turns out that a microorganism that maximizes
  its self-fabrication rate\, will only use one of such modes. Growth rate 
 maximizing cells should thus be as elementary as possible.However\, is the
 re an elementary way to select this optimal growth strategy? The number of
  Elementary Growth Modes in a typical metabolic network is incomputable\, 
 and only one of them is optimal. Complex and pathway-specific regulatory m
 echanisms might be able to find this optimum\, but these cost energy and m
 ight be hard to evolve. We try to imagine a cell that does not use complex
  regulatory mechanisms\, but rather self-organizes its way towards evoluti
 onary success.
LOCATION:Mondi Seminar Room 3\, Central Building\, ISTA
ORGANIZER:abonvent@ist.ac.at
SUMMARY:Daan de Groot and Age Tjalma: Elementary approaches to growth rate 
 maximization
URL:https://talks-calendar.ista.ac.at/events/2513
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