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DTSTART:20191027T020000
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DTSTAMP:20260404T110313Z
UID:5e183343540ea444670617@ist.ac.at
DTSTART:20200120T110000
DTEND:20200120T120000
DESCRIPTION:Speaker: Franck Maurinot\nhosted by Gaia Novarino\nAbstract: Th
 e mechanisms regulating the generation of the different types of neurons o
 f the vertebrate nervous system during development are still poorly unders
 tood. For my PhD project\, I characterized the composition and organizatio
 n of clones of neurons generated by retinal progenitor cells (RPCs) in chi
 cken embryos with the Brainbow strategy. This technique enables to permane
 ntly label RPCs with distinct color combinations in order to individually 
 trace their lineage. New approaches were developed to: i) trigger Brainbow
  labels at different stages of development or in genetically identified RP
 Cs\; ii) characterize in 3D the organization of retinal clones and identif
 y the neuronal types that they comprise. My results provide new informatio
 n on the phase of tangential dispersion of RPCs in the retinal neuroepithe
 lium before neurogenesis\, leading to uniform intercalation of retinal clo
 nes. The composition of these clones was analyzed to understand whether ea
 rly RPCs could be biased to generate certain neural types and\, through in
 tercalation\, contribute to their regular distribution in the retina. This
  study sheds light on the potentialities of a population of neural progeni
 tors and on the possible links between the early development and mature ce
 llular organization of a tissue through new approaches applicable to diver
 se problematics.
LOCATION:Mondi Seminar Room 1\, Central Building\, ISTA
ORGANIZER:lmarr@ist.ac.at
SUMMARY:Franck Maurinot: A lineage study of progenitor cells in the avian r
 etina: origin of neuronal classes and types
URL:https://talks-calendar.ista.ac.at/events/2512
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