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TZID:Europe/Vienna
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DTSTART:20170326T030000
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DTSTART:20161030T020000
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BEGIN:VEVENT
DTSTAMP:20260428T110247Z
UID:587cd2c86691a281611765@ist.ac.at
DTSTART:20170208T130000
DTEND:20170208T140000
DESCRIPTION:Speaker: Mantas Gabrielaitis\nhosted by Gašper Tkacik\nAbstrac
 t: Information about the auditory world enters the brain through auditory 
 nerve fibers. In mammals\, each of these fibers is exclusively driven by s
 ingle presynaptic active zones of inner hair cell ribbon synapses. Experim
 ental evidence suggests that exocytosis of separate presynaptic vesicles\,
  which is in turn induced by opening of individual Ca2+ channels\, at thes
 e active zones is sufficient to trigger action potentials in the auditory 
 nerve fibers. At first sight\, such a synaptic design maximizes contaminat
 ion of the signal transduction by thermal fluctuations\, and is inferior t
 o other synaptic types found in the nervous system. This idea\, however\, 
 is at odds with the fact that the auditory sensory system works with unpar
 alleled temporal precision over a wide range of stimulus intensities. In t
 his talk\, an explanation of the aforementioned contradiction will be pres
 ented. Results of a mathematical modeling study constrained by a wide rang
 e of experimental findings will be discussed. These results reveal the pre
 sence of several presynaptic strategies to suppress the deteriorating effe
 ct of the thermal fluctuations at the hair cell ribbon synapses. Consequen
 tly\, an apparently miserable synaptic setup is turned into an exemplary o
 ne.\n
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:jbeslagic@ist.ac.at
SUMMARY:Mantas Gabrielaitis: Molecular mechanisms of efficient coding at th
 e first auditory synapse
URL:https://talks-calendar.ista.ac.at/events/251
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