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DTSTAMP:20260404T110151Z
UID:1587481200@ist.ac.at
DTSTART:20200421T170000
DTEND:20200421T180000
DESCRIPTION:Speaker: Joachim Frank\nhosted by Leonid Sazanov\nAbstract: Thi
 s lecture will take place as a webinar.  All registered participants will
  receive a link to join the webinar.  In order to register\, please fill
  out the  registration form (https://istaustria.microsoftcrmportals.com/
 event/speakers?id=IST_Lecture_Joachim_Frank3445964213).Abstract:The aim of
  Structural Biology is to explain life processes in terms of macromolecula
 r interactions in the cell.   These interactions typically involve more 
 than two partners\, and can run up to dozens.  A full description will ne
 ed to characterize all structures on the atomic level\, and the way these 
 structures change in the process. Because of the crowded environment of th
 e cell\, such characterization is presently only possible when the group o
 f interacting molecules (often organized into processive “molecular mach
 ines”) is isolated and studied in vitro.  While X-ray crystallography h
 as provided structures of a large number of molecular structures\, the nee
 d for crystals diffracting to high resolution has severely limited the num
 ber of supramolecular assemblies and the range of conformers that can be s
 tudied with this technique.  Single-particle cryo-electron microscopy is 
 about to fill this gap\, allowing functional processes to be studied in gr
 eat detail without imposing restraints on the structures.  There are many
  examples now for this expansion of Structural Biology toward a full chara
 cterization of a functional process.This presentation will cover concept\,
  history and examples of the present capabilities of single-particle cryo-
 EM\, and its significance for Medicine.  It will then briefly cover the f
 uture prospects\, which include the study of short-lived intermediates in 
 a nonequilibrium system by time-resolved techniques\, and the characteriza
 tion of continuous structural changes using data mining from large ensembl
 es of molecule images.Biography:Joachim Frank is a Professor of the Depart
 ment of Biochemistry and Molecular Biophysics\, and a Professor of the Dep
 artment of Biological Sciences at Columbia University. Dr. Frank’s lab h
 as developed techniques of electron microscopy and single-particle reconst
 ruction of biological macromolecules\, specializing in mathematical and co
 mputational approaches.  He has applied these techniques of visualization
  to explore the structure and dynamics of the ribosome during the process 
 of protein synthesis.  In 2017 he shared the Wiley Prize in Biomedical Sc
 iences with Richard Henderson and Marin van Heel.  He was also awarded th
 e 2017 Nobel Prize in Chemistry together with Richard Henderson and Jacque
 s Dubochet. 
LOCATION:Webinar\, ISTA
ORGANIZER:arinya.eller@ist.ac.at
SUMMARY:Joachim Frank: [Webinar] Single-particle cryo-EM: Visualization of 
 biological molecules in their native states
URL:https://talks-calendar.ista.ac.at/events/2482
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