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DTSTART:20200329T030000
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DTSTART:20191027T020000
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DTSTAMP:20260405T191504Z
UID:5e1614d546bab318987791@ist.ac.at
DTSTART:20200203T100000
DTEND:20200203T110000
DESCRIPTION:Speaker: Franco Luis Lombino\nhosted by Ryuichi Shigemoto\nAbst
 ract: Microtubules (MTs) are involved in a variety of cellular functions t
 hroughout the entire neuronallifespan\, such as cell division and intracel
 lular cargo-transport. Katanin is composed by theregulatory subunit p80 an
 d the catalytic subunit p60. It is an enzyme that forms a hexamericring an
 d severs MTs via the hydrolysis of ATP\, and although previous data indica
 te that kataninplays a role in cell division and brain cortex formation\, 
 little is known about the function of thisenzyme during brain development 
 in vivo and in adult neurons.In our study\, we generated a constitutive kn
 ockout mouse for Katna1\, which encodes thecatalytic subunit of katanin an
 d investigated its role in brain development using a combinationof immunoh
 istochemical\, biochemical and in vivo techniques. On top\, we made use of
  anATPase-deficient p60 construct (p60-DEID) in order to dissect its role 
 in adult neurons in vitro.On the one hand\, our results indicate that Katn
 a1 homozygous knockout mice do not survive\,in agreement with a role of p6
 0 katanin in cell division. In addition\, we observed defects duringembryo
 nic and adult dentate gyrus (DG) neurogenesis in Katna1 heterozygous mice\
 , andthese defects did not impair hippocampal plasticity or learning and m
 emory in behavioral tasks.On the other hand\, our unpublished data suggest
  that p60 katanin is involved in synapticplasticity in adult hippocampal n
 eurons. Altogether\, we provide evidence that MT-severing bykatanin plays 
 a major role during development as well as in the adult brain.
LOCATION:Mondi Seminar Room 3\, Central Building\, ISTA
ORGANIZER:lmarr@ist.ac.at
SUMMARY:Franco Luis Lombino: The role of the microtubule-severing enzyme ka
 tanin in development\, memory formation and consolidation
URL:https://talks-calendar.ista.ac.at/events/2480
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