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DTSTART:20200329T030000
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DTSTART:20191027T020000
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DTSTAMP:20260405T161855Z
UID:5e145dbd3b0b1535025080@ist.ac.at
DTSTART:20200121T110000
DTEND:20200121T130000
DESCRIPTION:Speaker: Xavier Trepat\nhosted by Carl-Philipp Heisenberg\nAbst
 ract: Biological processes such as morphogenesis\, tissue regeneration\, a
 nd cancer invasion are driven by collective migration\, division\, and fol
 ding of epithelial tissues. Each of these functions is tightly regulated b
 y mechanochemical networks and ultimately driven by physical forces. I wil
 l present maps of cell-cell and cell-extracellular matrix (ECM) forces dur
 ing cell migration and division in a variety of epithelial models\, from t
 he expanding MDCK cluster to the regenerating zebrafish epicardium. These 
 maps revealed that migration and division in growing tissues are jointly r
 egulated. I will also present measurements of epithelial traction\, tensio
 n\, and luminal pressure in three-dimensional epithelia of controlled size
  and shape. By examining epithelial tension over time-scales of hours and 
 for extreme nominal strains we establish a remarkable degree of tensional 
 homeostasis mediated by superelastic behavior. Finally\, I will present di
 rect measurements of the forces that shape the intestinal organoid crypt.
LOCATION:Mondi Seminar Room 2\, Central Building\, ISTA
ORGANIZER:eghasemi@ist.ac.at
SUMMARY:Xavier Trepat: Engineering the shape and mechanics of epithelia
URL:https://talks-calendar.ista.ac.at/events/2472
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