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DTSTART:20170326T030000
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DTSTART:20161030T020000
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BEGIN:VEVENT
DTSTAMP:20260429T024212Z
UID:587756f579023342689785@ist.ac.at
DTSTART:20170125T130000
DTEND:20170125T140000
DESCRIPTION:Speaker: Stefania Tavano\nhosted by Carl-Philipp Heisenberg\nAb
 stract: Basal progenitors (BPs) are essential neuronal precursors that ser
 ve as an intermediate between highly proliferative apical progenitors and 
 post-mitotic neurons. Moreover\, the increase in the proliferative capacit
 y of BPs is considered a key evolutionary feature underlying the expansion
  of the human neocortex. Despite the significance of BPs in neocortical de
 velopment\, several aspects of BP biology are still unknown. For example\,
  how is BP production controlled molecularly.\nPreviously\, Insm1 was iden
 tified as a transcription factor important for BP production. Here\, we di
 scover that Insm1 induces delamination of neural progenitors from the vent
 ricular surface\, a step that is fundamental for BP production. Moreover\,
  we find that Insm1 down-regulates genes important for the homeostasis of 
 the adherens junction-belt and\, therefore\, possibly involved in the proc
 ess of delamination\, including the adherens junction-associated protein P
 lekha7. Through in vivo CRISPR-mediated KO\, we further demonstrate that P
 lekha7 is necessary to prevent delamination of neural progenitors. Our fin
 dings uncover a novel molecular regulatory mechanism for controlling BP pr
 oduction during neocortical development.
LOCATION:Meeting room on Bridge (former Neuroscience Room) (I04.3OG - LAB)\
 , ISTA
ORGANIZER:lalesch@ist.ac.at
SUMMARY:Stefania Tavano: Insm1 induces neural progenitor delamination in de
 veloping neocortex via down-regulat
URL:https://talks-calendar.ista.ac.at/events/247
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