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TZID:Europe/Vienna
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DTSTART:20200329T030000
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DTSTART:20191027T020000
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DTSTAMP:20260404T002317Z
UID:5d94aeb525bce102195661@ist.ac.at
DTSTART:20191213T150000
DTEND:20191213T160000
DESCRIPTION:Speaker: Michal Komorowski\nhosted by Gasper Tkacik\nAbstract: 
 An engineer designing a communication system would use few distinct signal
 ing components while ensuring that the output of each component is highly 
 accurate. Yet\, the engineer's perspective appears to be in sharp contrast
  with how cellular signaling systems operate. A single stimulus usually ac
 tivates several signaling effectors\, and cellular responses are marked wi
 th substantial cell-to-cell heterogeneity.In the talk\, I will present sev
 eral findings inspired by mathematical information-theory that seem to con
 tribute to reconciling the cross-wired architecture and cell-to-cell heter
 ogeneity with the engineer's expectations. Specifically\, I will discuss(i
 ) possible evolutionary origins of cross-wired architecture\, (ii) sources
  of the cell-to-cell heterogeneity of signaling responses\,(iii) and impli
 cations of the above for the design of therapeutic interventions.
LOCATION:Mondi Seminar Room 3\, Central Building\, ISTA
ORGANIZER:abonvent@ist.ac.at
SUMMARY:Michal Komorowski: Making sense of signaling complexity
URL:https://talks-calendar.ista.ac.at/events/2434
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