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DTSTART:20200329T030000
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DTSTART:20191027T020000
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DTSTAMP:20260405T215847Z
UID:5dce7c16dcdeb730207687@ist.ac.at
DTSTART:20191216T150000
DTEND:20191216T160000
DESCRIPTION:Speaker: Jake Watson\nhosted by Peter Jonas\nAbstract: Excitato
 ry synaptic transmission involves the presynaptic release of glutamate\, t
 o be detected by receptors localised at the postsynaptic membrane. Critica
 lly\, this transmission is plastic\, allowing information storage at these
  sites of intercellular communication. At the hippocampal CA1 synapse\, a 
 change in the number of postsynaptic AMPA receptors (AMPARs) responding to
  glutamate release is a principal mediator of synaptic plasticity. For thi
 s reason\, the mechanisms controlling synaptic AMPAR recruitment and ancho
 ring have been intensely studied for many years. While historic research h
 as focussed on intracellular receptor interactions in the postsynaptic den
 sity\, we have demonstrated that the extracellular region of the AMPAR\, w
 hich projects into the synaptic cleft\, is a critical mediator of AMPAR sy
 naptic anchoring. I will discuss how an interplay of intracellular and ext
 racellular AMPAR interactors with unique roles in AMPA receptor positionin
 g\, acts to control the strength of synaptic transmission. As extracellula
 r receptor interactions occur within the synaptic cleft\, both pre- and po
 stsynaptic neurons have the potential to control and detect the strength o
 f transmission\, with profound implications when considering how informati
 on is stored at a synaptic connection.
LOCATION:Seminar Room\, Lab Building East\, ISTA
ORGANIZER:ekrallib@ist.ac.at
SUMMARY:Jake Watson: Unravelling the interplay of AMPA receptor interaction
 s controlling synaptic strength
URL:https://talks-calendar.ista.ac.at/events/2433
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